Classification of Organic Nitrates 

Classification

Onset of action

Duration of action

Target organ

Examples

Short-acting nitrates

Rapid (within minutes)

Short (up to 30 minutes)

Coronary

Nitroglycerin (sublingual or spray), isosorbide dinitrate (sublingual)

Long-acting nitrates

Slow (within 30 minutes to 1 hour)

Long (up to 6-12 hours)

Coronary

Isosorbide mononitrate (oral), isosorbide dinitrate (oral or transdermal)

Coronary nitrates

Dilate coronary arteries

Improve myocardial blood flow


Nitroglycerin, isosorbide dinitrate

Venous nitrates

Dilate peripheral veins

Reduce preload on the heart


Isosorbide mononitrate, isosorbide dinitrate

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