Major Side effects of Nitroglycerine Major side effect is Peripheral Oedema Explanation: Nitroglycerine is a potent vasodilator, it Dephosphorylates the phosphorylated Myosin light chain and thereby prevents the actin-myosin crosslinking and relaxes the Vascular smooth muscle. In that way, Nitroglycerine increases the Vascular Permeability and more exudate can reach the peripheral Tissues resulting Oedema. Less Common Side Effects: Bloating or swelling of the face, arms, hands, lower legs, or feet Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings Difficult or labored breathing Feeling of warmth or heat Flushing or redness of the skin, especially on the face and neck Sweating Rare Side Effects: Bluish-colored lips, fingernails, or palms Dark urine Fever Pale skin Rapid heart rate Incidence Not Known: Arm, back, or jaw pain Blurred vision Symptoms of Overdose: Bluish-colored lips, fingernails, or palms Blurred or loss of vision
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