Low Molecular Weight Heparins (LMWHs) are a type of anticoagulant medication that work by inhibiting factor Xa, a key component in the blood clotting process.

Therapeutically, LMWHs are used to prevent and treat deep vein thrombosis (DVT) and pulmonary embolism (PE), conditions that occur when blood clots form in the deep veins of the body. 

MOA

It inhibits activated coagulation factors of the intrinsic and common pathways, including thrombin, Xa, and IXa; however, it has relatively little activity against factor VIIa. 

Low-molecular weight heparin preparations produce an anticoagulant effect mainly through inhibition of Xa by antithrombin, because the majority of molecules are of insufficient length to catalyze inhibition of thrombin.


THERAPEUTIC USES OF LMWHs

  1. Prevention of deep vein thromboses in the middle and high-risk populations (surgical, orthopedic, and medical patients).
  2. Treatment of pregnancy venous thromboembolism.

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