Classification of Fibrinolytic Agents based on their Target of Action 

Based on the Target of Action. Fibrinolytic Drugs are classified into 3 generations-

1st Generation: Acts by Fibrinolysis + Fibrinogenolytic action (Non-selective) 

  • Site of Action: Free Plasminogen and Fibrin found in Plasminogen (Less Specific).  
  • Examples: Streptokinase, Urokinase
  • Mode of Action: 
  1. Binds to Free Plasminogen: Depletes free fibrinogen (Fibrinogenolysis) Bleeding Complication 
  2. Binds to Fibrin bound Plasminogen: Fibrinolysis (Less Specific) 

2nd Generation: Acts by mostly on Fibrinolysis (75 % Selective)

  • Site of Action: Fibrin found in Plasminogen. 
  • Examples: Alteplase 
  • Mode of Action: 
  1. Binds with  Fibrin found in plasminogen (75%): Fibrinolysis 
  2. More Fibrin Specific (75%) 

3rd Generation: Acts selectively on Fibrinolysis (Selective)

  • Site of Action: Fibrin  bound Plasminogen. 
  • Examples: Reteplase, Monteplase 
  • Mode of Action: 
  1. Binds selectively with Fibrin Bound Plasminogen
  2. Activation of Plasmin 
  3. Fibrinolysis 



Mention the names of the drugs that acts as P2Y12 receptor inhibitors

Clopidogrel, Prasugrel

Clopidogrel, the first P2Y12 inhibitor, was the standard for DAPT until newer options became available.

Comments

Post a Comment

Popular posts from this blog

Image
MOA of Nitroglycerine  Nitroglycerine converted to NO (Active Metabolite)  NO bonds with Guanylyl cyclase and catalyzes the conversion of GTP to cyclic GMP. cGMP induces the enzyme Myosin LC phosphatase  Myosin-LC phosphatase dephosphorylates the phosphorylated myosin-LC (Contraction) to Myosin-LC (Relaxation)  Reducing Preload : Vasodilation promotes peripheral pooling of blood and decreases venous return to the heart , reducing preload. This results in decreased myocardial oxygen demand. Reducing Afterload : Arteriolar relaxation reduces systemic vascular resistance and arterial pressure, also known as afterload. This decreases the resistance the heart must overcome to eject blood, which reduces the workload of the heart. 
Read more
Image
Mechanism of Action of Angiotensin II Type- 1 (AT1) Receptor Blockers Angiotensin II receptor blockers (ARBs) are a class of medications that work by blocking the effects of angiotensin II, a powerful hormone that constricts blood vessels and raises blood pressure.  ARBs do this by binding to and blocking the angiotensin II type 1 receptor (AT1 receptor) , which is found in many tissues throughout the body, including the heart, blood vessels, and kidneys. When angiotensin II binds to the AT1 receptor, it causes a number of effects, including: Vasoconstriction (narrowing of blood vessels) Aldosterone release (a hormone that causes the kidneys to retain sodium and water) Catecholamine release (adrenaline and noradrenaline, which also raise blood pressure) Hypertrophic response (thickening of the heart muscle) By blocking the AT1 receptor, ARBs prevent these effects from occurring, which leads to a lowering of blood pressure.  ARBs are also known to have other beneficial effects, such as
Read more
Image
Classify antithyroid agents in terms of their mechanism of actions. Thyroid hormone synthesis inhibitors : These drugs inhibit the enzyme thyroid peroxidase, decreasing iodide oxidation, iodination of tyrosyl residues in thyroglobulin, and coupling of iodotyrosyl and iodothyronyl residues.  EXAMPLES : thioamides, which include propylthiouracil , methimazole , and its prodrug carbimazole. Iodide uptake inhibitors/ ionic Inhibitors : They decrease the uptake of iodide ions into follicular cells of the thyroid gland.  EXAMPLES : potassium perchlorate, pertechnetates, thiocyanates, and nitrates. Thyroid hormone release inhibitors : They inhibit the release of thyroid hormones by the thyroid gland. EXAMPLES : The most studied drug in this class is lithium . Thyroid hormone receptor antagonists : These drugs block the action of thyroid hormones at the cellular level. They do this by binding to thyroid hormone receptors and preventing thyroid hormones from exerting their effects. Examples in
Read more