Open-angle glaucoma is a chronic condition that can lead to vision loss due to damage to the optic nerve. This damage is often caused by an increase in intraocular pressure (IOP), which is the pressure inside the eye.

Prostaglandin agonists, such as travoprost and latanoprost, are often used as a first-line treatment for open-angle glaucoma. 

Mechanism Of Action:

  1. PGs binds with FP receptor of ciliary muscle cells inducing the expression of Matrix metalloprokinase (MMP) enzyme.
  2. MMP is responsible for the fragmentation of Collagen fibers. 
  3. Fragmentation of Collagen Fibers increases the Uveoscleral outflow (Aqueous humor outflow) to the extracellular space. 
  4. That results in decrease intraocular pressure reducing the risk of damage to the optic nerve. 



In summary, prostaglandin agonists can help arrest the progression of open-angle glaucoma by effectively reducing intraocular pressure, which is a key factor in the development of this condition

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