Serotonin reuptake inhibition and Depression 

Serotonin have potent anti-migraine activity by action on 5-HT1B/1D receptor.   

5-HT, or serotonin, is a neurotransmitter that plays a crucial role in mood regulation. Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs commonly used to treat depression. 
They work by inhibiting the reuptake of serotonin into neurons, which results in increased serotonin levels in the synaptic cleft enhancing its binding to post-synaptic neurons leading to increased Serotoninergic neurotransmission. 

Depression is a monoamine deficiency syndrome. So, the treatment may by in such a way in which the 5-HT level may be increased. This is done in 2 ways-
  1. Decreased MAO action: MAO is an enzyme, which is responsible for the metabolic breakdown of serotonin. Inhibiting the MAO, the overall concentration of Serotonin can be increased in the synaptic cleft. 
  2. Selective serotonin reuptake inhibitors (SSRIs) 

MODE of ACTION: (SSRIs) 

 




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