Hormone
Secretory Gland |
Released
Hormones |
Stimulated
By |
Somatotrophs |
GH
|
GHRH
(Growth hormone Releasing hormone) |
Lactotrophs |
Prolactin
|
GnRH
(Gonadotropin-releasing Hormone) |
Gonadotrophs |
LH,
FSH |
GnRH
(Gonadotropin-releasing Hormone) |
Corticotrophs |
ACTH
|
CRH
(Corticotropin-Releasing Hormone) |
Thyrotrophs |
TSH
|
TRH
(Thyrotropin releasing Hormone) |
Illustrate the mechanism of action of sulfonic urea used as oral hypoglycemic agents. Enumerate the role of insulin on glucose utilization. MOA of Sulfonyl Acid Derivatives Sulfonylureas ( Tolbutamide, Chlorpropamide ), a class of sulfonyl acid derivatives, have a significant action in lowering blood glucose levels in normal subjects and in type 2 diabetics . The mechanism of action of sulfonylureas involves provoking a brisk release of insulin from the pancreas. MOA: (1) They act on the so-called ‘sulfonylurea receptors’ (SUR1) on the pancreatic β cell membrane. (2) This action causes depolarization by reducing the conductance of ATP-sensitive K+ channels . (Raised ATP production followed by raised Glucose also reduces the conductance of ATP sensitive K+ Channels) (3) This process enhances Ca2+ influx (Followed by the stimulation of Voltage sensitive Ca++ Channel) and degranulation (followed by calcium dependent ...
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