Classification of Anticoagulant Drugs 





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 Classification of Fibrinolytic Agents based on their Target of Action  Based on the Target of Action. Fibrinolytic Drugs are classified into 3 generations- 1st Generation: Acts by Fibrinolysis + Fibrinogenolytic action (Non-selective)  Site of Action: Free Plasminogen and Fibrin found in Plasminogen (Less Specific).   Examples: Streptokinase, Urokinase Mode of Actio n:  Binds to Free Plasminogen: Depletes free fibrinogen (Fibrinogenolysis) Bleeding Complication  Binds to Fibrin bound Plasminogen: Fibrinolysis (Less Specific)  2nd Generation: Acts by mostly on Fibrinolysis (75 % Selective) Site of Action : Fibrin found in Plasminogen.  Examples : Alteplase  Mode of Action :  Binds with  Fibrin found in plasminogen (75%): Fibrinolysis  More Fibrin Specific (75%)  3rd Generation: Acts selectively on Fibrinolysis (Selective) Site of Action : Fibrin  bound Plasminogen.  Examples : Reteplase, Monteplase  M...
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In spite of its effective analgesic activity aspirin is used in prevention of formation of atherosclerotic disorder – explain why?? Aspirin , also known as  acetylsalicylic acid  ( ASA ), is a  nonsteroidal anti-inflammatory drug  (NSAID) used to reduce  pain ,  fever , and/or  inflammation , and as an  antithrombotic .   Aspirin is widely known for its analgesic (pain-relieving) properties, but it also plays a crucial role in the prevention of atherosclerotic disorders. Aspirin irreversibly inactivates the Cyclooxygenase Enzyme ( Prostaglandin Endoperoxide Synthase ) in the Arachidonic Acid Metabolism Pathway , and supress the production of Prostaglandin (PGs) and Thromboxane (TXs) and Prostacyclin ( Prostanoids ).  Atherosclerosis, also known as arteriosclerosis, is a condition where the arteries become thick and stiff due to the buildup of plaque. The plaque can also burst, leading to a blood clot.  ASPIRIN EFFECT ON PLAT...
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