Classification of Anticoagulant Drugs 





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Illustrate the mechanism of action of sulfonic urea used as oral hypoglycemic agents. Enumerate the role of insulin on glucose utilization. MOA of Sulfonyl Acid Derivatives Sulfonylureas ( Tolbutamide, Chlorpropamide ), a class of sulfonyl acid derivatives, have a significant action in lowering blood glucose levels in normal subjects and in  type 2 diabetics . The mechanism of action of sulfonylureas involves provoking a brisk release of insulin from the pancreas. MOA:  (1) They act on the so-called  ‘sulfonylurea receptors’ (SUR1)  on the pancreatic β cell membrane.  (2) This action causes  depolarization  by reducing the  conductance of ATP-sensitive K+ channels .  (Raised ATP production followed by raised Glucose also reduces the conductance of ATP sensitive K+ Channels) (3) This process enhances  Ca2+ influx  (Followed by the stimulation of Voltage sensitive Ca++ Channel)   and degranulation (followed by calcium dependent ...
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 Classification of Fibrinolytic Agents based on their Target of Action  Based on the Target of Action. Fibrinolytic Drugs are classified into 3 generations- 1st Generation: Acts by Fibrinolysis + Fibrinogenolytic action (Non-selective)  Site of Action: Free Plasminogen and Fibrin found in Plasminogen (Less Specific).   Examples: Streptokinase, Urokinase Mode of Actio n:  Binds to Free Plasminogen: Depletes free fibrinogen (Fibrinogenolysis) Bleeding Complication  Binds to Fibrin bound Plasminogen: Fibrinolysis (Less Specific)  2nd Generation: Acts by mostly on Fibrinolysis (75 % Selective) Site of Action : Fibrin found in Plasminogen.  Examples : Alteplase  Mode of Action :  Binds with  Fibrin found in plasminogen (75%): Fibrinolysis  More Fibrin Specific (75%)  3rd Generation: Acts selectively on Fibrinolysis (Selective) Site of Action : Fibrin  bound Plasminogen.  Examples : Reteplase, Monteplase  M...
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