Heparin Types 

Heparin Type

Description

Example

Standard heparin (unfractionated heparin or UFH)

Inhibits Factor Xa and IIa (1:1 ratio)

Heparin

Lower Molecular Weight Heparin (LMWH)

Majorly inhibits Factor Xa

Enoxaparin

Heparan Sulphate

 

Danaparoid

Fondaparinux

 

 

Mechanism of Oral Anticoagulants 

Vitamin K inhibitors

 


Antifactor Xa inhibitor

Apixaban Binds with Factor Xa

¯

Inhibits action of FXa

¯

¯ formation of Thrombin

¯

¯Rate of blood Clotting

Direct Thrombin Inhibitor

Binds to active site of Factor IIa

¯

Inactivate both free and fibrin bound thrombin

¯

¯ Thrombin

¯

¯Fibrin formation from fibrinogen

¯

¯ Coagulation




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