MOA of Neprilysin Inhibitor 


Heart failure is a chronic condition in which the heart is unable to pump enough blood to meet the body's needs. This can happen if the heart muscle is weakened or damaged, or if the heart valves do not work properly.

  • Neprilysin is an enzyme that breaks down a number of peptides, including natriuretic peptides. 
  • Natriuretic peptides are hormones that cause blood vessels to dilate and sodium to be excreted in the urine and Reduction in sympathetic Tone. 
  • By breaking down natriuretic peptides, neprilysin reduces their ability to lower blood pressure and fluid retention. 

  • Neprilysin inhibitors are a class of drugs that work by blocking the action of neprilysin. 
  • This allows natriuretic peptide levels to rise and 
  1. Reduction in sympathetic Tone,
  2. Vasodilation 
  3. decreased Aldosterone release (Increased Urination) 
As a result, overall improvement of Cardiac function Helps the heart work properly. 

Examples of neprilysin inhibitors used to treat chronic heart failure:

Sacubitril/valsartan (Entresto)

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