Various Therapeutic Uses of Somatostatin Analogues 

Somatostatin is a hormone produced by several tissues in the body, but it is mainly found in the nervous and digestive systems. It inhibits the secretion of several other hormones in the body and also acts as a neurotransmitter.
  • Somatostatin analogs are a synthetic form of somatostatin hormone and are used to reduce the production of various hormones in the body, particularly hormones produced by tumors.
Examples of Somatostatin Analogous: 

 

Mode of Action

Therapeutic Uses

Octreotide

Binds to Somatostatin Receptor (SSTR)s [Subtypes – 2,3,5]

-        ¯ Pancreatic Secretion

-        ¯ Gastric Acid Secretion

-        ¯ Intestinal Motility

-        Vasoconstriction à ¯ Blood Flow

-        ¯ GnRH, GH, LH

 

Acromegaly

Diarrhoea

GEP neuroendocrine Tumors.

Lanreotide

 

SSTR – 2, SSTR – 5 (Less Affinity)

¯ IGF-1

¯

Inhibits the growth of neuroendocrine Tumors

¯

¯ Secretion of GH [Excessive]

¯

Treatment of Acromegaly

 

 

Acromegaly

Hypotension

Neuroendocrine Tumors

 

Pasireotide

 

(Long Acting)

SSTR – 1,2,3,4,5

-        Inhibit Secretion of Glucagon, Insulin, GH.

Cushing Syndrome

Acromegaly

Zollinger – Ellison syndrome


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