E.g., Thiocyanate, Nitrates MOA: These drugs have structural similarities with the iodide ion, so they compete with iodide for being transported by the sodium/iodide symporter, a protein that co-transports Na + and I − ions across the cell membrane. By reducing the availability of iodide, these drugs inhibit the key step in the biosynthesis of thyroid hormones.
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The most common treatment for hypothyroidism is taking synthetic thyroid hormones, such as levothyroxine (Levo-T, Synthroid, and others), every day. This medication restores the normal levels of thyroid hormones in the body and eliminates the symptoms of hypothyroidism, such as fatigue, weight gain, cold intolerance, constipation, dry skin, and hair loss.
Hormone Secretory Gland Released Hormones Stimulated By Somatotrophs GH GHRH (Growth hormone Releasing hormone) Lactotrophs Prolactin GnRH (Gonadotropin-releasing Hormone) Gonadotrophs LH, FSH GnRH (Gonadotropin-releasing Hormone) Corticotrophs ACTH CRH (Corticotropin-Releasing Hormone) Thyrotrophs TSH TRH (Thyrotropin releasing Hormone)
Various Therapeutic Uses of Somatostatin Analogues Somatostatin is a hormone produced by several tissues in the body, but it is mainly found in the nervous and digestive systems . It inhibits the secretion of several other hormones in the body and also acts as a neurotransmitter. Somatostatin analogs are a synthetic form of somatostatin hormone and are used to reduce the production of various hormones in the body, particularly hormones produced by tumors. Examples of Somatostatin Analogous: Mode of Action Therapeutic Uses Oct reotide Binds to Somatostatin Receptor (SSTR)s [Subtypes – 2,3,5] - ¯ Pancreatic Secretion - ¯ Gastric Acid Secretion - ¯ Intestinal Motility - Vasoconstriction à ¯ Blood Flow - ¯ GnRH, GH, LH Acromegaly Diarrhoea GEP neuroendocrine Tumors. Lan reotide SSTR – 2, SSTR – 5 (Less Affinity